Neolon

Composition:

Each 1 ml contains:

Neomycin sulphate 200 mg 

(Eq. to neomycin base 140 mg)

Properties:

Neomycin is an antibiotic from the aminoglycoside family. Its spectrum of action includes many Gram -ve germs and in particular E. coli and Enterobacteriaceae. 

Aminoglycosides bind to the 30S ribosomal subunit of the bacteria by binding to the ribosome, aminoglycosides inhibit the translocation of tRNA during translation and therefore inhibit the synthesis of proteins necessary for the growth of the bacteria.

Target species:  Broiler chickens and turkey for meat production.

Indications: 

  For the treatment of:

Colibacillosis (Bacterial enteritis) caused by E. coli, and other Gram-negative bacteria (as salmonella) susceptible to neomycine sulphate. 

Dosage & Route of administration: 

Route:

Taken orally via drinking water.

Dose:

–  For broiler chicken and turkey for meat production:

1.4 – 2 ml of the product / liter per day for 3 to 5 consecutive days.

– For Pre-ruminating calves, sheep, goats, pigs, rabbits:

0.7 – 1 ml of the product / 10 kg b. wt. every 12 hours for 3 – 5 consecutive days.

Precaution for human (uses): 

-People with known hypersensitivity to aminoglycosides should avoid contact with the veterinary medicinal product. Ifyou develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention. 

– Wash hands after use.

Precaution for animal:

This oral solution is intended to be dispersed in water. 

Avoid administration in case of severe renal impairment. 

At low concentrations, all aminoglycosides can only be bacteriostatic.

– Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. 

– If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria. Official, national and regional antimicrobial policies should be taken into account when the product is used. 

– Use of the product deviating from the instructions given in this leaflet may increase the prevalence of bacteria resistant to neomycin and may decrease the effectiveness of treatment with aminoglycosides due to the potential for cross resistance. 

– Special care should be taken when considering to administer the product to the pre-ruminating calves due to the known higher gastrointestinal absorption of neomycin. 

– This higher absorption could lead to an increased risk of oto- and nephrotoxicity. 

The use of the product in neonates should be based on the benefit/ risk determination from the attending veterinarian.

Precaution during pregnancy, lactation and laying:

-The safety of the product has not been evaluated in the target species. 

-The use of the medicinal product will depend on the evaluation of the benefit veterinarian.

Contra-indications:

* Do not administer to animals known to be allergic to aminoglycosides or to the excipients or in the presence of intestinal obstruction.

Side effects:

Classically aminoglycosides are poorly absorbed (less than 10%) from the digestive tract. However, enteritis and other pathological changes may allow greater absorption and, in renal failure, the appearance of toxic levels resulting in acute tubular necrosis with secondary interstitial lesion.

Poisoning:

Non-oliguric renal failure is the usual clinical situation in aminoglycoside poisoning; it is usually reversible although healing may be delayed. Monitor renal function carefully during treatment: polyuria, decreased urinary osmolarity, enzymuria, proteinuria, cylindruria and increased sodium excretion fraction are signs of aminoglycoside nephrotoxicity Ototoxic effects may occur in case of an accidental overdose.

Drug-Drug interaction:

– Some aminoglycosides are more efficiently transported to the cell membrane than others, and thus have greater antibacterial activity Synergy is common when aminoglycosides and β-lactam cephalosporins) are used in combination. The lesion of the cell wall induced by β-lactam compounds allows a high incorporation of aminoglycosides by the bacterial cell due to greater accessibility to the cell membrane.

-Renal toxicity may become evident with simultaneous administration membrane of aminoglycosides and other potentially toxic agents (methoxyflurane, amphotericin B, cisplatin and some cephalosporins).

-General anaesthetics and muscle relaxing products increase the neuro- blocking effect of aminoglycosides. This may cause paralysis and apnoea. Special care should be taken when using concurrently with strong diuretics and potentially oto- or nephrotoxic substances.

Withdrawal time:  

Pre-ruminating calves: 14 days. 

Broiler chicken: 14 days. 

Sheep, goats, pigs & turkey for meat production: 14 days. 

Rabbits: 14 days

Storage condition:

Stored at temp not exceeding 30 ᵒC.

Package: 

500 ml & 1 liter in white opaque plastic (HDPE) bottles sealed with aluminum seal lined inside by plastic (HDPE) film closed by white opaque plastic (HDPE) cap with an outer label.