Vaxflagy

    Each 100 gm contains:

    Metronidazole                           20 gm

    Amoxicillin(as trihydrate)      10    gm

      Vaxflagy  is a combined antibacterials containing amoxicillin and metronidazole.  

      Amoxicillin is a beta-lactam antibiotic and its structure contains the beta-lactam ring

    and thiazolidine ring common to all penicillins.It prevents the bacterial cell wall

    from forming by interfering with the final stage of peptidoglycan synthesis. It

    inhibits the activity of transpeptidase enzymes which catalyse cross linkage of the

    glycopeptides polymer units that form the cell wall.It exerts a bactericidal action but

    causes lysis of growing cells only. It can be referred to as a time dependent

    antibiotic. It is active against some Gram negative bacteria and most Gram positive

    bacteria as Penicillin sensitive pasteurella spp., Proteus spp., Streptococcus spp.,

    E.coli and Gram positive cocci. Metronidazole is a concentration dependent

    bactericidal agent against susceptible bacteria. Its exact mechanism of action is taken

    up by anaerobic organisms where it is reduced to an unidentified polar compound. It

    is believed that this compound is responsible for the drug’s antimicrobial activity by

    disrupting DNA and nucleic acid synthesis in the bacteria. It has activity against

    most obligate anaerobes including Bacteroides spp. (including B. fragilis),

    Fusobacterium veillonella, Clostridium spp., Peptococcus spp.and Peptostreptococcus

    spp. Actinomyces is frequently resistant to metronidazole. Some  isolates of C.difficile

    may be resistant. Metronidazole is is also trichomonacidal and amebicidal in action and

    acts as a direct amebicide. It has therapeutic activity against Entamoeba histolytica,

    Trichomonas spp., Giardia spp. and Balantidium coli. It acts primarily against the

    trophozoite forms of Entamoeba rather than encysted forms.

    Poultry – Dogs – Cats.

      For the treatment of:

    • Giardiosis caused by Giardia duodenalis.
    • Rhinitis caused by Pasteurella spp. and Streptococcus spp.
    •  Bronchopneumonia caused by Pasteurella spp., Escherichia coli and Gram-

    positive cocci.

    • Pyelonephritis and infections of the lower urinary tract caused by Escherichia coli,

    Proteus spp. and Gram-positive cocci.

    • Endometritis caused by Escherichia coli, Streptococcus canis and Proteus  spp.
    • Local skin infections caused by Streptococcus spp.

    Route of administration: Taken orally via drinking water

    For whole product: 1 gm of product / 10 kg b.wt . twice daily for a minimum of 5 consecutive days . the majority of routine cases respond after between 5 and 7 days of therapy . if no improvement is observed after 5- 7 days, the diagnosis should be re-assessed . in chronic or refractory cases .a longer course of therapy may be required.

    • If the drug must be used in animals with significant liver impairment, consider reducing the total daily  dose to 1/3 of standard anti-anaerobe dosage and dose once daily.
    • Because of the risk for neurotoxicity in dogs, total daily doses of metronidazole should not exceed 65 mg / kg per day.
    • In animals with hepatic and renal dysfunction, the dosing regimen should be carefully evaluated and the use of the product based on a risk/benefit evaluation by the veterinary surgeon.
    • the product should only be used based on susceptibility testing.
    • Do not use in case of hypersensitivity to penicillins or other substances of the β- lactam group.
    • Do not use in case of hypersensitivity to metronidazole or other nitroimidazole  derivatives
    • Do not use in case of severly debilitated, pregnant or nursing animals.
    • Do not use in animals with  hepatic dysfunction.   
    • Neurologic disorders, lethargy, weakness, neutropenia, hepatotoxicity, hematuria, anorexia, nausea, vomiting & diarrhea.
    • Allergic skin reactions & anaphylaxis.
    • Not applicable.

    Store at a temperature not exceeding  30°C in a dry place, used immediately after opening and reconstitution

    HDPE opaque plastic jar contains: LDPE colorless plastic bag contains

    500 gm powder and tightened with LDPE white plastic seal strip, the jar covered by HDPE opaque plastic cap with HDPE safety seal with outer label only.

    Composiation:

    Each 100 gm contains:

    Metronidazole                           20 gm

    Amoxicillin(as trihydrate)      10    gm

    Properties:

      Vaxflagy  is a combined antibacterials containing amoxicillin and metronidazole.  

      Amoxicillin is a beta-lactam antibiotic and its structure contains the beta-lactam ring  

      and thiazolidine ring common to all penicillins.It prevents the bacterial cell wall  

      from forming by interfering with the final stage of peptidoglycan synthesis. It  

      inhibits the activity of transpeptidase enzymes which catalyse cross linkage of the  

      glycopeptides polymer units that form the cell wall.It exerts a bactericidal action but  

      causes lysis of growing cells only. It can be referred to as a time dependent  

      antibiotic. It is active against some Gram negative bacteria and most Gram positive  

      bacteria as Penicillin sensitive pasteurella spp., Proteus spp., Streptococcus spp.,  

      E.coli and Gram positive cocci. Metronidazole is a concentration dependent  

      bactericidal agent against susceptible bacteria. Its exact mechanism of action is taken  

      up by anaerobic organisms where it is reduced to an unidentified polar compound. It  

      is believed that this compound is responsible for the drug’s antimicrobial activity by  

      disrupting DNA and nucleic acid synthesis in the bacteria. It has activity against  

      most obligate anaerobes including Bacteroides spp. (including B. fragilis),  

      Fusobacterium veillonella, Clostridium spp., Peptococcus spp.and Peptostreptococcus  

      spp. Actinomyces is frequently resistant to metronidazole. Some  isolates of C.difficile  

      may be resistant. Metronidazole is is also trichomonacidal and amebicidal in action and  

      acts as a direct amebicide. It has therapeutic activity against Entamoeba histolytica,  

      Trichomonas spp., Giardia spp. and Balantidium coli. It acts primarily against the  

      trophozoite forms of Entamoeba rather than encysted forms.

     

    Target species:  Poultry – Dogs – Cats. 

    Indications: 

      For the treatment of:

    • Giardiosis caused by Giardia duodenalis. 
    • Rhinitis caused by Pasteurella spp. and Streptococcus spp. 
    •  Bronchopneumonia caused by Pasteurella spp., Escherichia coli and Gram- 

     positive cocci.

    • Pyelonephritis and infections of the lower urinary tract caused by Escherichia coli,  

         Proteus spp. and Gram-positive cocci.

    • Endometritis caused by Escherichia coli, Streptococcus canis and Proteus  spp.
    • Local skin infections caused by Streptococcus spp. 

         

    Dosage & Route of administration:  

    Route of administration: Taken orally via drinking water

    For whole product: 1 gm of product / 10 kg b.wt . twice daily for a minimum of 5 consecutive days . the majority of routine cases respond after between 5 and 7 days of therapy . if no improvement is observed after 5- 7 days, the diagnosis should be re-assessed . in chronic or refractory cases .a longer course of therapy may be required.

    Warning & precaution:

    • If the drug must be used in animals with significant liver impairment, consider reducing the total daily  dose to 1/3 of standard anti-anaerobe dosage and dose once daily.
    • Because of the risk for neurotoxicity in dogs, total daily doses of metronidazole should not exceed 65 mg / kg per day.
    • In animals with hepatic and renal dysfunction, the dosing regimen should be carefully evaluated and the use of the product based on a risk/benefit evaluation by the veterinary surgeon.
    • the product should only be used based on susceptibility testing.  

    Contra-indications:

    • Do not use in case of hypersensitivity to penicillins or other substances of the β- lactam group.
    • Do not use in case of hypersensitivity to metronidazole or other nitroimidazole  derivatives
    • Do not use in case of severly debilitated, pregnant or nursing animals.
    • Do not use in animals with  hepatic dysfunction.                                                                                                  

    Side effects:

    • Neurologic disorders, lethargy, weakness, neutropenia, hepatotoxicity, hematuria, anorexia, nausea, vomiting & diarrhea.
    • Allergic skin reactions & anaphylaxis.

    Withdrawal time:  

    • Not applicable.

    Storage:   

    Store at a temperature not exceeding  30°C in a dry place, used immediately after opening and reconstitution

    Packaging:  HDPE opaque plastic jar contains: LDPE colorless plastic bag contains

     500 gm powder and tightened with LDPE white plastic seal strip, the jar covered by HDPE opaque plastic cap with HDPE safety seal with outer label only. 

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