Vetcarestine

Composition

Each 1 ml contains:

Colistin sulphate       240 mg  (eq. to  5,760,000   IU)

Properties:

Colistin is a polypeptide antibiotic belonging to the class of polymyxin.

Colistin has a bactericidal action on sensitive bacterial strains , by disorganization of their cytoplasmic membrane , leading to an alternation of cell permeability and thus to a loss of intracellular material 

Colistin has bactericidal power against a broad spectrum of Gram-negative bacteria , including enterobacteria and in particular Escherichia  coli , Colistin has a very little activity against Gram-Positive bacteria and fungal organisms . 

Gram-Positive bacteria , as well as some species of Gram-negative bacteria such as proteus and Serratia , are naturally resistant to colistin 

However, the acquisition of resistance of gram- negative enteric bacteria to colistin is rare and can be explained by simple mutation.

Colistin exhibits concentration-dependent activity against Gram-negative bacteria .Following oral administration, high concentrations are observed in the gastrointestinal tract . i.e., the target site due to the low absorption of the substance.

Colistin is a polymyxine bactericidal polypeptide antibiotic. It produces its antibacterial effect by interacting strongly with phospholipids in bacterial cell membrane & radically disturbed their permeability & function. Colistin is active against G -ve bacteria such as Pseudomonas , E. coli ,Klebsiella , Aerobacter , Enterobacter , Salmonella , Shigella & Haemophilus.

Indications :

It is used for the treatment of gastrointestinal tract infections caused by G – ve Colistin sensitive bacteria (ex: E.coli).

Target species:

broiler chickens. 

Dosage and administration :

Route of administration: taken  Orally Via drinking water.

Dosage: 

• For Whole product :

1. B) broiler Chickens:13 ml of product / 1000 kg.b.wt.in drinking water daily for 3-7 days(1.3 ml\10 liter))

Duration of treatment should be limited to the minimum time necessary for the treatment of the disease. 

Treatment duration should not exceed 7 days.

 

Warning and precautions:

Special warnings for each target species:

Colistin exerts concentration- dependent activity against Gram-negative bacteria. Following oral administration high concentration are achieved in gastrointestinal tract , i.e. the target site , due to the poor absorption of the substance . these factors indicate that a longer duration of treatment than the one indicated In dosage section leading to unnecessary exposure is not recommended 

Special precautions for use in animals:

-Do not use colistin as a substitute for good management practices .

-Colistin is a last resort drug in human medicine for treatment of infectious caused by certain multi-drug resistant bacteria . In order to minimize any potential risk associated with widespread use of colistin . its use should be limited to treatment or treatment and metaphylaxis of disease , and should not be used for prophylaxis 

-Whenever possible. colistin should only be used based on susceptibility testing .

-Use of the product deviating from the instructions given in the insert may lead to treatment failures and increase the prevalence of bacteria resistant to colistin 

Contraindications :.

Do not use in horses, particularly in foals, since colistin, due to a shift in the gastrointestinal micro flora balance could lead to the development of antimicrobial associated colitis (Colitis X), typically associated with Clostridium difficile, which may be fatal.

Withdrawal time: 

pigs : meat and offal : 2 days

 broiler chicken:

Meat and offal: 1 day.

Eggs: zero days.

Storage conditions:

• Store at temperature not exceeding 30◦C  and used immediately after opening.

Packaging :

• 250 ml oral solution in opaque plastic HDPE container sealed with aluminium seal lined inside by HDPE plastic film closed by opaque plastic HDPE cap with outer label